Science Driven

The oral microbiome at the interface of health & disease

Are we really autonomous organisms ? The microorganisms inside and on our bodies that live on all our barrier tissues are more than residents. Their number is at least equal to the number of our own cells (Sender R. et al., 2016) and they have coevolved with us to form a functional organ that plays a significant role in our health and physiology (Kilian M. et al., 2017). Together we form a superorganism, also called holobiont. Our mouth harbors the second most diverse microorganisms community in the body (after the gut), including viruses, fungi, protozoa, archaea and bacteria (Wade WG. et al., 2013).
The characterization and understanding of this oral microbial community has accelerated dramatically through the advent of Next Generation Sequencing based methods. Metagenomics, metatrancriptomics, as well as metabolomics are tools currently used to decipher the complexity of our oral microbiota and its interaction with our immune system, as well as with our environment (Kilian M. et al., 2017).

It is now well understood that a dysbiosis of the oral microbiota is associated with two of the most common bacterial diseases in human: dental caries (tooth decay) and periodontal (gum) diseases. This paves the way for new approaches in the management of these diseases.

OralNext provides you with the necessary knowledge to incorporate this shift in your clinical practice. Instead of managing the caries and periodontitis by a systematic elimination of the microbiota, OralNext gives you the tools to re-establish the symbiotic equilibrium synonymous with a healthy state.

The OralNext methodology includes individual assessment of the host response for the early detection of subjects at high risk, and personalized approaches to restore the health-associated oral microbiome after dysbiosis.